![]() The concept of multiple opioid receptors was first suggested almost 50 years ago (Martin, 1967), opening the possibility of new classes of drugs, but the morphine-like agents have remained the mainstay in the medical management of pain. Thus, it is not surprising that new agents were initially based upon the morphine scaffold. Opium contains high concentrations of both morphine and codeine, along with thebaine, which is used in the synthesis of a number of semisynthetic opioid analgesics. ![]() ![]() Although pain is the current focus, early use initially focused upon the treatment of dysentery. Opiates are among the oldest medications available to manage a number of medical problems. ![]()
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March 2023
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